Competing pathways control host resistance to virus via tRNA modification and programmed ribosomal frameshifting
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Competing pathways control host resistance to virus via tRNA modification and programmed ribosomal frameshifting
Viral infection depends on a complex interplay between host and viral factors. Here, we link host susceptibility to viral infection to a network encompassing sulfur metabolism, tRNA modification, competitive binding, and programmed ribosomal frameshifting (PRF). We first demonstrate that the iron-sulfur cluster biosynthesis pathway in Escherichia coli exerts a protective effect during lambda ph...
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ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2012
ISSN: 1744-4292,1744-4292
DOI: 10.1038/msb.2011.101